With Whole Genome Sequencing, is it guaranteed that researchers will identify the disease-causing genetic variant and thus, provide an accurate diagnosis for the patient?

Genomic medicine is still a relatively new field of scientific research. While Whole Genome Sequencing enables us to read and sequence the over 3 billion DNA bases in a human genome, to enhance the diagnostic rate, finding out whether a genetic variant is linked with a disease requires research with a large number of clinical cases. It will take time and resources for healthcare professionals and scientists to conclusively identify disease-causing variants for many patients.